Assessment of new drug potential using publicly available data
Keywords
scRNA-Seq & bulk RNA-seq
Public datasets
Neurodegenerative disorder
Challenge
A customer wanted to assess the potential of a new drug for a range of possible applications and assess the applicability of Alzheimer’s in vivo model for other neurological disorders.
Solution
BISC Global performed data mining of public data repositories, targeted gene expression analysis to determine a list of potential genes, gene clusters and pathways of interest. After performing phenotype linkage, BISC Global was able to establish a list of phenotypes most likely to respond well to its drugs.
Impact
BISC Global was able to use existing data to reduce the customer’s clinical trial costs and perform more targeted new clinical trials for its new drugs.