Characterize immune repertoires in transgenic animals, infectious diseases and cancer

KEYWORDS: Cancer | Custom pipeline development | Immune repertoire | Antibodies | Immunology

Challenge

One of our customers is involved in antibody engineering, working with transgenic animals that produce antibodies. It was unknown how well those antibodies resemble the human variant and the customer needed data to quantify this equivalency to share the findings with partners and customers.

Solution

Our team developed a high-throughput immune repertoire processing pipeline that supports the analysis of more than 20 species. We used public BCR data to compare key repertoire characteristics and dynamics. Furthermore, we made the pipeline compliant with AIRRTSV data standards.

Impact

With the analysis pipeline developed by BISC Global, the customer was able to quantify the resemblance between the antibodies produced by the transgenic animals and the equivalents present in humans. This information enabled our customer to offer enhanced quality assurance to their customers and differentiate themselves from competitors.