Characterize immune repertoires in transgenic animals, infectious diseases and cancer

Challenge

One of BISC’s customers is involved in antibody engineering. They work with transgenic animals, which produce their antibodies. It was unknown though how well those antibodies resemble the human variant. The customer wanted data to quantify this equivalency to be able to share this with its partners and customers.

Solution

BISC developed a high-throughput Immune repertoire processing pipeline which supports the analysis for more than 20 species. Public BCR data was used to compare key repertoire characteristics and dynamics. Furthermore the pipeline was made compliant to AIRRTSV data standards.

Impact

With the analysis pipeline developed by BISC Global, the customer was able to quantify the resemblance between their antibodies and its human equivalents. With this information, they can offer enhanced quality assurance to their customers and differentiate themselves from their competitors.

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