Image Processing & Machine Learning for medical device

Challenge

A customer was interested in finding new potential targets for siRNAs based on their existing databases.

Solution

BISC Global performed a study combining following analyses:

  • siRNA hit calling and determining on/off targets
  • Selection of siRNA’s for subsequent toxicity screen
  • Define thresholds for cell viability, toxicity, household gene stability

Impact

BISC Global identified compelling on/off-target interactions with limited effects on cell viability and toxicity.

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