Integrated public single cell re-analysis reveals rare intermediate cell type in neurodegenerative disease
KEYWORDS: scRNA-Seq & bulk RNA-seq | Therapeutic targets discovery | Public datasets | Neurodegenerative disorder | Oligodendrocytes
Challenge
BISC’s customer is involved in remyelination research. Remyelination is a key process to heal the brain after traumatic or disease-related injury. Uncovering driver mechanisms could result in therapeutic targets for chronic neurodegenerative disease where remyelination fails.
Solution
Integration of multiple public single-cell RNA repositories, combined with extensive downstream analysis, trajectory analysis and regulatory network inference.
Impact
- Clarification of differentiation process beyond the state-of-the-art
- Creation of a unique data repository to mine for novel markers
- Confirmation and discovery of new therapeutic targets
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