Integrated public single cell re-analysis reveals rare intermediate cell type in neurodegenerative disease

Keywords

scRNA-Seq & bulk RNA-seq

Therapeutic targets discovery

Public datasets

Neurodegenerative disorder

Oligodendrocytes

Challenge

BISC’s customer is involved in remyelination research. Remyelination is a key process to heal the brain after traumatic or disease-related injury. Uncovering driver mechanisms could result in therapeutic targets for chronic neurodegenerative disease where remyelination fails.

Solution

Integration of multiple public single-cell RNA repositories, combined with extensive downstream analysis, trajectory analysis and regulatory network inference. 

Impact

  • Clarification of differentiation process beyond the state-of-the-art
  • Creation of a unique data repository to mine for novel markers
  • Confirmation and discovery of new therapeutic targets

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