Integrated public single cell re-analysis reveals rare intermediate cell type in neurodegenerative disease

KEYWORDS: scRNA-Seq & bulk RNA-seq | Therapeutic targets discovery | Public datasets | Neurodegenerative disorder | Oligodendrocytes

Challenge

BISC’s customer is involved in remyelination research. Remyelination is a key process to heal the brain after traumatic or disease-related injury. Uncovering driver mechanisms could result in therapeutic targets for chronic neurodegenerative disease where remyelination fails.

Solution

Integration of multiple public single-cell RNA repositories, combined with extensive downstream analysis, trajectory analysis and regulatory network inference.