PK/PD Modeling For Dose Regulation

Challenge

A customer requested help to assess the right dosage of a drug based on host enzyme kinetics and physiological factors.

Solution

BISC Global helped this customer by:

  • Defining compartments of interest in the host
  • Performing equations for enzyme kinetics
  • Implementing physiological data for dosage
  • Performing differential equations for dose regulation

Dosage over time for compartments of interest was established.

Impact

Through BISC Global’s efforts the customer was able to obtain better efficacy for their treatment. It also lead to regulating treatments for different diseases based on host genetics.

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